Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach

The recent outbreak of the highly contagious coronavirus disease 2019 (COVID-19) caused by novel SARS-CoV-2 has created a global health crisis with socioeconomic impacts. Although, recently, vaccines have been approved for prevention COVID-19, there is still an urgent need discovery more efficacious and safer drugs especially from natural sources. In this study, number quinoline quinazoline alkaloids antiviral and/or antimalarial activity were virtually screened against three potential targets development COVID-19. Among seventy-one tested compounds, twenty-three selected molecular docking based on their pharmacokinetic toxicity profiles. results identified inhibitors. Three them, namely, norquinadoline A, deoxytryptoquivaline, deoxynortryptoquivaline, showed strong binding to targets, main protease, spike glycoprotein, human angiotensin-converting enzyme 2. These therefore promise being further investigated as possible multitarget